The Lazzara Lab studies fundamental and applied aspects of mammalian cell signaling and receptor trafficking.
Signaling regulation by the epidermal growth factor receptor (EGFR), protein tyrosine phosphatase SHP2, and multipurpose protein Sprouty2, and the impact on cancer response to targeted therapies, have been areas of recent interest. The lab also studies receptor-mediated processes in renal physiology that maintain the normal glomerular filtration barrier and enable the reabsorption of filtered proteins from the proximal tubule. A combination of experimentation and computational modeling approaches (mechanistic and data-driven) are employed to study these problems.

Open Positions

The Lazzara Lab seeks enthusiastic applicants to fill open positions for postdoctoral research associates, graduate research assistants, laboratory technical staff, and undergraduate researchers with a start date of August 1, 2016 or later. Candidates should send a current c.v. to mlazzara@seas.upenn.edu or mlazzara@virginia.edu.


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The Lazzara Lab is very excited to be moving to the University of Virginia in August 2016! Positions are open!

Lazzara Lab awarded new NIH R21 funding to collaborate with lab of Dr. Damien Thevenin (Lehigh University) to study signaling regulation by PTPRJ/DEP1 (Dec 2015).

Lazzara Lab awarded NSF CBET grant to study signaling regulation by SHP2 in glioblastoma (Aug 2015).

Matt Lazzara is the recipient of a 2015 Research Scholar Grant from the American Cancer Society (July 2015).

Janine Buonato's paper on the role of SHP2 in EMT published in the Journal of Cell Science.

Chris Furcht's paper published in Science Signaling. "EGFR-activated Src family kinases maintain GAB1-SHP2 complexes distal from EGFR."

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